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Comparison of the Characteristics of Breast Milk-derived Stem Cells with the Stem Cells Derived from the Other Sources: A Comparative Review

Author(s):

Ebrahim Rahmani-Moghadam, Vahideh Zarrin, Amir Mahmoodzadeh, Marzieh Owrang and Tahereh Talaei-Khozani*  

Abstract:


Breast milk (BrM) not only supplies nutrition, but it also contains a diverse population of cells. It has been estimated that up to 6% of the cells in human milk possess the characteristics of mesenchymal stem cells (MSC). Available data also indicate that these cells are multipotent and capable of self-renewal and differentiation with other cells. In this review, we have compared different characteristics, such as CD markers, differentiation capacity, and morphology of stem cells, derived from human breast milk (hBr-MSC) with human bone marrow (hBMSC), Wharton's jelly (WJMSC), and human adipose tissue (hADMSC). Through the literature review, it was revealed that human breast milk-derived stem cells specifically express a group of cell surface markers, including CD14, CD31, CD45, and CD86. Importantly, a group of markers, CD13, CD29, CD44, CD105, CD106, CD146, and CD166, were identified, which were common in the four sources of stem cells. WJMSC, hBMSC, hADMSC, and hBr-MSC are potently able to differentiate into the mesoderm, ectoderm, and endoderm cell lineages. The ability of hBr-MSCs todifferentiate into the neural stem cells, neurons, adipocyte, hepatocyte, chondrocyte, osteocyte, and cardiomyocytes has made these cells a promising source of stem cells in regenerative medicine, while isolation of stem cells from the commonly used sources, such as bone marrow, requires invasive procedures. Although autologous breast milk-derived stem cells are an accessible source for women who are in the lactation period, breast milk can be considered as a source of stem cells with high differentiation potential without any ethical concern.

Comparison, of, the, Characteristics, of, Breast, Milk-derived, Stem, Cells, with, the, Stem, Cells, Derived, from, the, Other, Sources:, A, Comparative, Review

Affiliation:

Department of Anatomical sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Laboratory for Stem Cell Research, Shiraz University of Medical Sciences, Shiraz, Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Department of Anatomical sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Department of Anatomical sciences, School of Medicine, Shiraz University of Medical Sciences, Shiraz



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