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Mesenchymal Stromal Cell Secretome: Immunomodulation, Tissue Repair and Effects on Neurodegenerative Conditions

Author(s):

Fatima Zriek, John A Di Battista and Nada Alaaeddine*   Pages 1 - 14 ( 14 )

Abstract:


Mesenchymal stromal cells (MSCs) have emerged as a modern development in therapeutics for a wide variety of diseases. Secreted paracrine factors constitute the principal components harboring the restorative promise of MSCs. Recent studies demonstrate that MSC-derived secretomes are composed of several molecules targeting a variety of biological processes that impact tissue repair, growth and immunomodulation. Indeed, secretomes interact with immune cells, activating regulatory anti-inflammatory phenotypes. In this review, we discuss the action of MSC-derived secretomes in promoting tissue regeneration, opposing the inflammatory response in context specific cases, and treating neurodegenerative diseases resulting from chronic neuroinflammation.

Keywords:

Mesenchymal stromal cells, secretome, conditioned medium, inflammation, regeneration, neurodegenerative diseases.

Affiliation:

Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut, Division of Rheumatology and Clinical Immunology, Royal Victoria Hospital, McGill University, Montreal, QC, Neuroscience Research Center, Faculty of Medical Sciences, Lebanese University, Beirut



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