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Plasma-Rich in Growth Factor and its Clinical Application


Mohsen Sheykhhasan, Amelia Seifalian and Alexander Seifalian*   Pages 1 - 15 ( 15 )


The potential use of growth factors in stem cell-based therapies for the repair and regeneration of tissues and organs offers a paradigm shift in regenerative medicine. Growth factors are critical signalling molecules that play an important role in tissue development and remodelling. Plasma Rich in Growth Factor (PRGF) is a biotechnological strategy for the harvesting of the active substances of platelets, including growth factors, from the patient’s blood. Because of their tremendous essential growth factor and bioactive agents, as well as their paracrine mechanisms, PRGF has been used as an efficacious option and adjuvant biological therapy in the repair and replacement of damaged organs. This article provides an overview of PRGF extraction and its properties and critically reviewed its clinical benefit and clinical trials in the treatment and regeneration of human organs. Regenerative medicine is a multi-billion-dollar industry with huge interest to clinicians, academics and industries, being considered as an emerging technology.


Plasma Rich in Growth Factor, regenerative medicine, ophthalmology, orthopaedic, dermatology, dentistry, stem cells, human organs, tissue remodelling, cosmetic, growth factors, clinical, fat cells.


Research Centre for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, University College London Medical School (UCL), London, Watford General Hospital, Watford

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