Tahereh Ebrahimi, Mozhgan Abasi, Fatemeh Seifar, Shirin Eyvazi, Mohammas Saeid Hejazi, Vahideh Tarhriz* and Soheila Montazersaheb* Pages 133 - 144 ( 12 )
Stem cells are considered to have significant capacity to differentiate into various cell types in humans and animals. Unlike specialized cells, these cells can proliferate several times to produce millions of cells. Nowadays, pluripotent stem cells are important candidates to provide a renewable source for the replacement of cells in tissues of interest. The damage to neurons and glial cells in the brain or spinal cord is present in neurological disorders such as Amyotrophic lateral sclerosis, stroke, Parkinson’s disease, multiple sclerosis, Alzheimer’s disease, Huntington’s disease, spinal cord injury, lysosomal storage disorder, epilepsy, and glioblastoma. Therefore, stem cell transplantation can be used as a novel therapeutic approach in cases of brain and spinal cord damage. Recently, researchers have generated neuron-like cells and glial-like cells from embryonic stem cells, mesenchymal stem cells, and neural stem cells. In addition, several experimental studies have been performed for developing stem cell transplantation in brain tissue. Herein, we focus on stem cell therapy to regenerate injured tissue resulting from neurological diseases and then discuss possible differentiation pathways of stem cells to the renewal of neurons.
Stem cells, neurological disorders, injured brain, spinal cord, Huntington’s disease, pluripotent.
Department of Biotechnology research center, Pasteur institute of Iran, Tehran, Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Stem Cell Research Center, Aging Research institute, Tabriz University of Medical Sciences, Tabriz, Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz