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The Use of Mathematical Modelling for Improving the Tissue Engineering of Organs and Stem Cell Therapy

[ Vol. 11 , Issue. 8 ]


Greg Lemon, Sebastian Sjoqvist, Mei Ling Lim, Neus Feliu, Alexandra B. Firsova, Risul Amin, Ylva Gustafsson, Annika Stuewer, Elena Gubareva, Johannes Haag, Philipp Jungebluth and Paolo Macchiarini   Pages 666 - 675 ( 10 )


Regenerative medicine is a multidisciplinary field where continued progress relies on the incorporation of a diverse set of technologies from a wide range of disciplines within medicine, science and engineering. This review describes how one such technique, mathematical modelling, can be utilised to improve the tissue engineering of organs and stem cell therapy. Several case studies, taken from research carried out by our group, ACTREM, demonstrate the utility of mechanistic mathematical models to help aid the design and optimisation of protocols in regenerative medicine.


Regenerative medicine, tissue engineering, stem cell therapy, stem cells, mathematical modelling, computational modelling.


Laboratory of Bioengineering and Regenerative Medicine, Kazan Federal University, Kazan, Russia.

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