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Reduced-Intensity Stem Cell Transplantation for Hematological Malignancies: Current Status and the Future

[ Vol. 2 , Issue. 2 ]

Author(s):

Koji Kato, Yasser Khaled and Shin Mineishi   Pages 149 - 162 ( 14 )

Abstract:


Reduced-intensity stem cell transplantation (RIST) has opened a new era for hematopoietic stem cell transplantation (HSCT). It was developed based on the knowledge that graft-versus-tumor (GVT) effect is the main anti-tumor effect in allogeneic HSCT. Because RIST is associated with less morbidity and mortality, it can be applied to many patients who could not undergo conventional HSCT. Experiences in the last decade clarified many issues related to RIST. For example, graft-versus-host disease (GVHD) in RIST may differ in character compared to conventional HSCT. Also, it is now known that intensity of conditioning is important in disease control, and the optimal regimens may be different for each disease or for each disease status. There are still many unsolved questions, and large prospective randomized trials are necessary to resolve these.

Keywords:

Reduced-intensity stem cell transplantation, graft-versus-host disease, graft-versus-leukemia effect, mixed chimerism, regimen-related toxicity

Affiliation:

Blood and Marrow Transplantation Program, University of Michigan Comprehensive Cancer Center, 5303 CCGC 1500E, Medical Center Drive, Ann Arbor, MI 48109-0914, USA.



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