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The concurrent therapeutic potential of adipose-derived mesenchymal stem cells on Gentamycin-induced hepatorenal toxicity in rats

Author(s):

Mohamed A Rawash, Ayman Saber Mohamed * and Emad M El-Zayat  

Abstract:


Background: Adipose mesenchymal stem cells (AMSCs) are a type of stem cell employed to repair damaged organs. This study aimed to see how effective AMSCs are at treating gentamycin-induced hepatorenal damage in rats.

Methods: 18 male Wister rats were assigned into three groups; control, Gentamycin (GM), and GM+AMSCs. GM induced hepatorenal toxicity through daily injection (100 mg/kg, i.p.) for eight days. On day 9, AMSC (106 cells/ml/rat) was injected intravenously.

Results: Creatinine, urea, uric acid, AST, ALP, ALT, TNF-, and MDA levels decreased, whereas IL-10, GSH, and CAT levels increased, indicating the therapeutic potency of intravenous injection AMSCs.

Conclusion: The current study demonstrated the simultaneous therapeutic efficacy of adipose mesenchymal stem cells on the liver and kidney in the treatment of Gentamycin-induced hepatotoxicity. These data show that AMSCs could be a feasible therapy option for liver and kidney disease.

Keywords:

Adipose-derived mesenchymal stem cells, Gentamycin, Aminoglycosides, Hepatorenal toxicity, Oxidative stress, Histology, Inflammation

Affiliation:

Biotechnology Department, Faculty of biotechnology, October University for Modern Sciences and Arts (MSA) , Zoology Department, Faculty of Science, Cairo University, 12613, Giza, Zoology Department, Faculty of Sciences, Cairo University



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