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Regulation of Neurogenesis and Neuronal Differentiation by Natural Compounds

Author(s):

Jing An, Bo Chen*, Ding Tian, Yunshan Guo, Yuzhu Yan and Hao Yang*  

Abstract:


Neuronal damage or degeneration is the main feature of neurological diseases. Regulation of neurogenesis and neuronal differentiation is important in developing therapies to promote neuronal regeneration or synaptic network reconstruction. Neurogenesis is a multistage process in which neurons are generated and integrated into existing neuronal circuits. Neuronal differentiation is extremely complex because it can occur in different cell types and can be caused by a variety of inducers. Recently, natural compounds that induce neurogenesis and neuronal differentiation have attracted extensive attention. In this paper, the potential neural induction effects of medicinal plant-derived natural compounds on neural stem/progenitor cells (NS/PCs), the cultured neuronal cells, and mesenchymal stem cells (MSCs) are reviewed. The natural compounds that are efficacious in inducing neurogenesis and neuronal differentiation include phenolic acids, polyphenols, flavonoids, glucosides, alkaloids, terpenoids, quinones, coumarins, and others. They exert neural induction effects by regulating signal factors and cell-specific genes involved in the process of neurogenesis and neuronal differentiation, including specific proteins (β-tubulin III, MAP-2, tau, nestin, neurofilaments, GFAP, GAP-43, NSE), related genes and proteins (STAT3, Hes1, Mash1, NeuroD1, notch, cyclin D1, SIRT1, reggie-1), transcription factors (CREB, Nkx-2.5, Ngn1), neurotrophins (BDNF, NGF, NT-3) and signaling pathways (JAK/STAT, Wnt/β-catenin, MAPK, PI3K/Akt, GSK-3β/β-catenin, Ca2+/CaMKII/ATF1, Nrf2/HO-1, BMP). The natural compounds with neural induction effects are of great value for neuronal regenerative medicine and provide promising prevention and treatment strategies for neurological diseases.

Keywords:

Natural compounds, neurogenesis, neuronal differentiation, neurite outgrowth, neural stem/progenitor cells, neuronal cells, mesenchymal stem cells.

Affiliation:

Translational Medicine Centre, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Translational Medicine Centre, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Translational Medicine Centre, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Clinical Lab, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Translational Medicine Centre, Honghui Hospital, Xi’an Jiaotong University, Xi’an



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