Aishwarya L, Dharmarajan Arun and Suresh Kannan
In future, neurodegenerative diseases will take over cancer's place and become the major cause of death in the world, especially in developed countries. Advancements in the medical field and its facilities have led to an increase in the old age population, and thus contributing to the increase in number of people suffering from neurodegenerative diseases. Economically it is of a great burden to society and the affected family. No current treatment aims to replace, protect, and regenerate lost neurons; instead, it alleviates the symptoms, extends the life span by a few months and creates severe side effects. Moreover, people who are affected are physically dependent for performing their basic activities, which makes their life miserable. There is an urgent need for therapy that could be able to overcome the deficits of conventional therapy for neurodegenerative diseases. Stem cells, the unspecialized cells with the properties of self-renewing and potency to differentiate into various cells types can become a potent therapeutic option for neurodegenerative diseases. Stem cells have been widely used in clinical trials to evaluate their potential in curing different types of ailments. In this review, we discuss the various types of stem cells and their potential use in the treatment of neurodegenerative disease based on published preclinical and clinical studies.
Stem cells, Neurodegenerative diseases, Conventional therapy, regeneration Preclinical and Clinical trial
Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai-600 116, Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai-600 116, Department of Biomedical Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai-600 116