Xiansi Zeng, Wenshuo Geng, Jinjing Jia* and Zhanqi Wang Pages 958 - 969 ( 12 )
Parkinson’s disease (PD) is a common neurodegenerative disease and is a major culprit that harms the health of elderly people. The main pathological feature is the progressive loss of dopaminergic neurons in the substantia nigra pars compacta of the midbrain. The current mainstream therapeutic strategies include surgical treatment and medicine substitute therapy. However, these treatment methods sometimes have limitations. Subsequently, the treatment with stem cells (SCs) transplantation has been gradually established. SCs is a kind of cell with self-renewal ability and multi-directional differentiation potential. Transplantation of SCs, including embryonic stem cells, adult stem cells (neural stem cells and mesenchymal stem cells) and induced pluripotent stem cells, have the ability to mediate nerve regeneration and restoration within the lesioned midbrain tissue, bringing hope for the treatment of PD. In this paper, we summarize the progress in therapeutic strategies of different types of SCs in PD treatment, with an emphasis on the advantages and limitations.
Parkinson's disease, Stem cells, Cell therapy, neurodegenerative, substantia nigra pars compacta, striatum.
Department of Biochemistry,Jiaxing University Medical College, Jiaxing 314001, College of Life Sciences, Xinyang Normal University, Xinyang 464000, Department of Physiology, Jiaxing University Medical College, Jiaxing 314001, College of Life Sciences, Huzhou University, Huzhou 313000