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Quality of Life in Patients with β-thalassemia Major: Short-term and Long-term Effects After Haematopoietic Stem Cell Transplantation

[ Vol. 16 , Issue. 8 ]

Author(s):

Lu Zhai, Yuhua Liu, Rongrui Huo, Zhaofang Pan, Juan Bin, Zhi Li, Qiaomei Tang and Jing Fan*   Pages 924 - 930 ( 7 )

Abstract:


Background: Allogeneic haematopoietic stem cell transplantation (ALLO-HSCT) is a potentially curative approach to treat β-thalassemia major (β-TM).

Objective and Methods: To assess the quality of life (QOL) of patients with β-TM after ALLO-HSCT, we searched PubMed, Embase, Web of Science, and MEDLINE for articles on the quality of life (QOL) of patients with β-TM from 1 Feb 2020 to 31 Mar 2020.

Results: Our review revealed that the QOL of patients with β-TM after ALLO-HSCT from a sibling donor is higher than that of patients that received blood infusion and iron-chelating therapy. Survivors of ALLO-HSCT have a QOL as good as that of a healthy population and the ability to return to normal life. However, studies thus far are limited to investigations with a few patients with β-TM who received ALLO-HSCT of the bone marrow (BM) from a sibling donor or related donor. Graft vs. host disease, patient age, gender, sexual desire, health condition, psychological state, financial and employment stress, and social support contributed to a worse QOL after ALLO-HSCT. Medicine usage, physical therapy, and psychological intervention may help improve the decline in QOL related to ALLO-HSCT in patients with β-TM.

Conclusion: Doctors and nurses must focus on implementing medicine usage, physical therapy, and psychological intervention to improve the decline in QOL related to ALLO-HSCT.

Keywords:

Quality of life, β-thalassemia major, haematopoietic stem cell transplantation, blood infusion, iron-chelating therapy, bone marrow.

Affiliation:

Department of Stem Cell Transplantation, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Hepatobiliary Surgery, Affiliated Tumour Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, Department of Stem Cell Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi



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