Ozge Burcu Sahan and Aysen Gunel-Ozcan* Pages 1 - 20 ( 20 )
Imbalance between free radicals and antioxidants causes oxidative stress by the accumulation of reactive oxygen species (ROS) in the tissues and organs. Oxidative stress occurs in many damage conditions, and the increase of ROS and reduction of antioxidants enhances inflammation, apoptosis, fibrosis and may worsen the pathology leading to organ failure. The potential therapies aim to increase antioxidants and decrease ROS. Mesenchymal stem cells (MSCs) isolated from the stroma of various tissues are multipotent cells and have beneficial effects on several diseases with their immunomodulation and regeneration capacities. MSCs trigger the proliferation of the cells with various secretory factors, reduce the oxidative stress and decrease apoptosis, inflammation, fibrosis and thus increase the regeneration. However, survival, engraftment and differentiation problems of transplanted MSCs restrict their protective and regenerative effects. Preconditioning of MSCs with several factors such as cytokines, hypoxia, chemical agents, pharmocological drugs, physical factors and growth factors enhances their repairing efficacy for injury and disease models. This review is mainly focused on insulin-like growth factor (IGF-1) and hepatocyte growth factor (HGF), and discusses the research on MSC priming/induction with IGF-1 and HGF stimulation either by supplementation or overexpression can enhance regenerative potential of MSCs on various oxidative stress conditions such as acute/chronic kidney diseases, lung injury, cancer, metabolic and cardiovascular diseases.
Oxidative stress, reactive oxygen species, mesenchymal stem cells, preconditioning, insulin-like growth factor, hepatocyte growth factor
Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Ankara, Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Ankara