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Applications of Umbilical Cord Derived Mesenchymal Stem Cells in Autoimmune and Immunological Disorders: From Literature to Clinical Practice

Author(s):

Bahareh Abbaspanah, Samira Reyhani and Seyed Hadi Mousavi*   Pages 1 - 11 ( 11 )

Abstract:


Mesenchymal stem cells (MSCs) enable a novel approach in stem cell therapy. Bone marrow (BM) was the first source used in MSCs therapy. However, BM has a number of key limitations as a source of MSCs, such as existence of only a small number of MSCs in the tissue, the painful, ethically problematic, and invasive nature of the associated collection process, and decrease in MSC specifications as age of donors increases. As a result, there has been increasing scholarly attention in identifying alternative sources for MSCs. In specific, Umbilical Cord Mesenchymal Stem Cells (UC-MSCs) has been identified as a valuable source from which MSC may be obtained with potentially fewer ethical issues. MSCs can regulate the immune response, promote tissue repair, increase regeneration, and improve anticancer effects. Thus, they are significant allogenic and autologous representative for curing malignant and non-malignant disorders. In this review, therefore, the prospective applications for curing autoimmune disorders will be considered.

Keywords:

Umbilical Cord, Mesenchymal Stem Cells, Autoimmune disease, Stem cell therapies, bone marrow, non-malignant disorders.

Affiliation:

Royan Stem Cell Technology Company, Cord blood bank, Tehran, Department of Laboratory Sciences, School of Allied Medical sciences, Tehran University of Medical sciences, Tehran, Department of Hematology, School of Allied Medical Sciences, Tehran University of Medical sciences, Tehran



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