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Potential of Combination of Bone Marrow Nucleated and Mesenchymal Stem Cells in Complete Spinal Cord Injury

Author(s):

Shojiro Katoh, Vidyasagar Devaprasad Dedeepiya, Satoshi Kuroda, Masaru Iwasaki, Rajappa Senthilkumar, Senthilkumar Preethy and Samuel JK Abraham*   Pages 1 - 15 ( 15 )

Abstract:


Background: Cell-based therapies represent one of the definitive treatment approaches to SCI which to become a routine clinical application is marred by several known unknowns. The bone marrow mononuclear cells (BMMNCs) and mesenchymal stem cells (MSCs) represent the most clinically applied cell types for SCI in humans, with safety established and to an extent, efficacy reported.

Methods: In this review we have analysed the clinical studies done using BMMNC and MSC for complete SCI separately and the potential for applying those cells in combination. We have also analysed those factors whose outcome in animal studies of SCI could be evaluated in depth but the clinical outcome cannot be evaluated intrinsically owing to practical difficulties.

Conclusion: A combination of these two cell types, BMMNC and MSC has been proven to be advantageous than applying them separately. Therefore, a thorough evaluation including rationale and potential implications of applying these two therapies has been presented here and we hypothesize that such a combination is likely to improvise the outcome of a wholesome approach to spinal cord regeneration after SCI.

Keywords:

Bone marrow mononuclear cells (BMMNC), Mesenchymal Stem Cells (MSC), Spinal Cord Injury (SCI), Non-cell based regenerative therapies, Spinal cord regeneration, Cell- based therapies.

Affiliation:

Edogawa Evolutionary Laboratory of Science (EELS), Edogawa Hospital, 2-24-18 Higashikoiwa, Edogawa, 133-0052, Tokyo, The Mary-Yoshio Translational Hexagon (MYTH), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai - 600094, Department of Neurosurgery, Graduate School of Medicine and Pharmacological Science, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Yamanashi University- Faculty of Medicine, 1110, Shimokato, Chuo, Yamanashi, 409-3898, The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai - 600094, The Fujio-Eiji Academic Terrain (FEAT), Nichi-In Centre for Regenerative Medicine (NCRM), Chennai - 600094, Edogawa Evolutionary Laboratory of Science (EELS), Edogawa Hospital, 2-24-18 Higashikoiwa, Edogawa, 133-0052, Tokyo



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