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Human Exfoliated Deciduous Teeth Stem Cells: Features and Therapeutic Effects on Neurogenerative and Hepatobiliary-Pancreatic Diseases

Author(s):

Nurul Wahidah Abdul Wahab, Rhanye Mac Guad, Vetriselvan Subramaniyan, Ismail M. Fareez, Ker Woon Choy, Srinivasa Reddy Bonam, Chandrasekaran Selvaraju, Maw Shin Sim, Subash C.B. Gopinath* and Yuan Seng Wu*   Pages 1 - 14 ( 14 )

Abstract:


Stem cells can multiply into more cells with similar types in an undifferentiated form and differentiate into other types of cells. The great success and key essence of stem cell technology is the isolation of high-quality mesenchymal stem cells (MSCs) with high potency, either with multipotent or pluripotent property. In this line, stem cells from human exfoliated deciduous teeth (SHEDs) are highly proliferative stem cells from dental pulp and have multipoint differentiation capacity. These cells play a pivotal role in regenerative medicine, such as cell repair associated with neurodegenerative, hepatobiliary, and pancreatic diseases. In addition, stem cell therapy has been widely used to regulate immune response and repair of tissue lesions. This overview captured the differential biological characteristics, and the potential role of stem cell technology and paid special attention to human welfare SHEDs in eliminating the abovementioned diseases. This review provides further insights into stem cell technology by expanding the therapeutic potential of SHEDs in tissue engineering and cell organ repairs.

Keywords:

Totipotency, pluripotent, human exfoliated deciduous teeth, SHEDs, neurodegenerative disease, retinal degeneration, liver diseases, diabetes mellitus, organ transplantation

Affiliation:

Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, Department of Biomedical Science and Therapeutics, Faculty of Medicine and Health Science, Universiti Malaysia Sabah, Kota Kinabalu 88400, Sabah, Department of Pharmacology, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor 42610, Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Selangor 42610, Department of Anatomy, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh 47000, Selangor, Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, 15 rue de l’Ecole de Médicine, F-75006, Paris, Department of Early Clinical Exposure and Personal and Professional Development, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor 42610, Department of Pharmaceutical Life Sciences, Faculty of Pharmacy, University of Malaya, Kuala Lumpur 50603, School of Bioprocess Engineering, Universiti Malaysia Perlis, Arau 02600, Perlis, Department of Biochemistry, School of Medicine, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Selangor 42610



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