Submit Manuscript  

Article Details


The Application of Nucleic Acids and Nucleic Acid Materials in Antimicrobial Research

Author(s):

Yue Sun, Ronghui Zhou, Lingxian Meng, Yuxin Zhang, Dan Zhao and Xiaoxiao Cai*   Pages 1 - 8 ( 8 )

Abstract:


Due to the abusing of antibiotics, multiple drug-resistant pathogenic bacteria have increasingly emerged. It increases the difficulty of treatment as it directly affects public health by diminishing potency of existing antibiotics. Developing alternative therapeutic strategies is the urgent need to reduce the mortality and morbidity related to drug-resistant bacterial infections. In the past 10 to 20 years, nanomedicines have been widely studied and applied as an antibacterial agent. It has become a novel tool for fighting resistant bacteria. The most common innovative substance, metal and metal oxide nanoparticles (NPs), has been widely reported. Until recently, DNA nanostructures used alone or functionalized with specific DNA sequences many scholars for antimicrobial purpose which alternatively selected as therapy for bacterial severe infections. It is a potential candidate of treatments and has a considerable prospect of killing antibiotic-resistant bacteria. This review involves the dimensions of multidrug resistance and the mechanism of bacteria developing drug resistance. The importance of this article is that we summarized the current study of nano-materials based on nucleic acids in antimicrobial use. Meanwhile, the current progress and the present obstacles for its antibacterial therapeutic use and special function of stem cells in this field would also be discussed.

Keywords:

Antibiotic resistance, Antibacterial, Nucleic acid aptamers, Antisense oligonucleotides (ASOs), Antimicrobial peptides (AMP), DNA nanostructures, Metallic nanoparticles

Affiliation:

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu



Read Full-Text article