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Nanomaterials and Aging

Author(s):

Chen-Chen Mao and Xiaoxiao Cai*   Pages 1 - 9 ( 9 )

Abstract:


Nowadays, with the increasing proportion of the aging population, more and more elderly people suffer from aging-related diseases. Evidences said that aging may be the result of genetic regulation. Even if aging is inevitable, prolonging the time of healthy aging, delaying the progression of aging-related diseases and the incidence of morbidity can greatly alleviate the pressure on individuals and society. Today, the research and exploration of aging in the field of materials is increasing. Here, we have a rough summary of recent researches of aging in the field of nanomaterials. Some nanomaterials such as silica NMs and carbon nanotubes can cause damage to the cells, which may due to aging. Other nanomaterials such as Fullerenes and metal based nanomaterials with reducing properties can protect the body from endogenous and exogenous harmful substances such as ROS to some extent by virtue of their excellent reducing properties. Another new type of nucleic acid nanomaterial, Tetrahedral framework nucleic acids, is not limited to avoiding cell damage. It selectively clearance existing senescent cells in the tissue, and this effect also avoids the chronic inflammatory environment caused by senescent cells secreting senescence-associated secretory phenotype to the surroundings. We believe that the potential in the field of nanomaterials is enormous, and today's research results are just the tip of the iceberg. There are still a lot of space of nanomaterials to explore in the aging field.

Keywords:

nanomaterial, aging, senescence, carbon based nanomaterials, metal based nanomaterials, tetrahedral framework nucleic acids [tFNAs].

Affiliation:

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu



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