Submit Manuscript  

Article Details


Mesenchymal Stem Cells Differentiation: Mitochondria Matter in Osteogenesis or Adipogenesis Direction

Author(s):

Kun Ji , Ling Ding, Xi Chen , Yun Dai, Fangfang Sun, Guofeng Wu * and Wei Lu*   Pages 1 - 5 ( 5 )

Abstract:


Mesenchymal stem cells (MSCs) have exhibited enormous therapeutic potential because of their indispensable regenerative, reparative, angiogenic, anti-apoptotic, and immunosuppressive properties. MSCs can best differentiate into mesodermal cell lineages including osteoblasts, adipocytes, muscle cells, endothelial cells and chondrocytes. Specific differentiation of MSCs could be induced through limited conditions. In addition to the relevant differentiation factors, drastic changes also occur in microenvironment to conduct it in an optimal manner for particular differentiation. Recent evidence suggests that the behavior of mitochondria participates in the regulating on direction and process of MSCs differentiation. Therefore, our current review focuses on how the behavior of mitochondria participates in both osteogenesis and adipogenesis of MSC differentiation. Besides that, in our current review, we try to provide an further understanding of the relationship between the behavior of mitochondria and the direction of MSC differentiation, which could optimize current cellular culturing protocols for benefit further tissue engineering by adjusting specific conditions of stem cells.

Keywords:

mitochondria, mesenchymal stem cells, osteogenesis, adipogenesis, metabolism, ageing, hypoxia

Affiliation:

Pediatric Dentistry Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University , Prosthodontics Department, Nanjing Stomatological Hospital, Medical School of Nanjing University



Read Full-Text article