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Cancer Stemness as a Target for Immunotherapy is Shaped by Proinflammatory Stress

[ Vol. 16 , Issue. 7 ]


Nese Unver*   Pages 792 - 800 ( 9 )


Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in multi-step tumorigenesis, tumor recurrence and metastasis. Proinflammatory stress is highly associated with cancer stemness via induction of cytokines, tumorpromoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.


Inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines, immunotherapeutic strategies.


Department of Stem Cell Sciences, Graduate School of Health Sciences, Center for Stem Cell Research and Development, Hacettepe University, Sihhiye, 06100, Ankara

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