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Cancer stem cells represent a rare subpopulation of cancer cells carrying self-renewal and differentiation features in the multi-step tumorigenesis, tumor recurrence and metastasis. Pro-inflammatory stress is highly associated with cancer stemness via induction of cytokines, tumor-promoting immune cells and cancer stemness-related signaling pathways. This review summarizes the major pro-inflammatory factors affecting cancer stem cell characteristics and the critical immunotherapeutic strategies to eliminate cancer stem cells.
inflammation, cancer stemness, pro-inflammatory stress, cancer stem cells, pro-inflammatory cytokines
Hacettepe University, Department of Stem Cell Sciences, Center for Stem Cell Research and Development, Sihhiye, 06100