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Mesenchymal Stem Cell Therapy for Patients with Ischemic Heart Failure- Past, Present, and Future

Author(s):

Fang Chen*, Peng Liang , Fang Ye, Cong-Cong Hou and Lin Pi   Pages 1 - 14 ( 14 )

Abstract:


The prevalence of heart failure (HF) has increased over time. Ischemic heart failure accounts for 50% of HF, which results from ischemic coronary heart diseases such as myocardial infarction (MI). Conventionally, reduction of cardiac load and revascularization partially increase cardiomyocyte survival and preserve cardiac functions. Nevertheless, how to improve cardiomyocyte rescue and prevent HF progression remain as challenges. Mesenchymal stem cells (MSCs) are multipotent stem cells that give rise to various lineages. Administration of MSCs promotes cardiomyocyte survival and improves cardiac functions in animal models of MI and patients with ischemic cardiomyopathy. However, after injection, MSCs persist for a very short time, indicating that the prolonged protective effects of MSCs on cardiomyocytes may be mediated by paracrine functions of MSCs, such as exosomes. In this review, we focus on MSC-derived exosomes in cardiomyocyte protection to facilitate future applications of exosomes in HF treatment.

Keywords:

heart failure, ischemic cardiomyopathy, mesenchymal stem cells, exosomes, cardiomyocytes

Affiliation:

Chui Yang Liu Hospital, Tsinghua University, Department of Cardiology, Department of Cardiology, Chui Yang Liu Hospital, Tsinghua University, Beijing 110105, Department of Cardiology, Chui Yang Liu Hospital, Tsinghua University, Beijing 110105, Department of Cardiology, Chui Yang Liu Hospital, Tsinghua University, Beijing 110105, Department of Cardiology, Chui Yang Liu Hospital, Tsinghua University, Beijing 110105



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