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Exosome and Biomimetic Nanoparticle Therapies for Cardiac Regenerative Medicine

Author(s):

Ke Cheng*, Sydney Stine, Kristen Popowski and Teng Su   Pages 1 - 10 ( 10 )

Abstract:


Exosome and biomimetic nanoparticles have great potential to develop into a wide-scale therapeutic platform within the regenerative medicine industry. Exosomes, a subgroup of EVs whose diameter ranges from 30-100 nm, have recently gained traction as an innovative approach for the treatment of various diseases, including heart disease. Their beneficial factors and regenerative properties can be contrasted between various cell types. Various biomimetic nanoparticles have also emerged as a unique platform in regenerative medicine. Biomimetic nanoparticles are a drug delivery platform that have the ability to contain both biological and fabricated components to improve therapeutic efficiency and targeting. The novelty of these platforms holds promise for future clinical translation upon further investigation. In order for both exosome therapeutics and biomimetic nanoparticles to translate to large-scale clinical treatment, numerous factors must first be considered and improved. Standardization of different protocols, from exosome isolation to storage conditions, must be optimized to ensure batches are pure. Standardization is also important to ensure there is no variability in this process across studies, thus making it easier to interpret data across different disease models and treatments. Expansion of clinical trials incorporating both biomimetic nanoparticles and exosomes will require a standardization of fabrication and isolation techniques, as well as stricter regulations to ensure reproducibility across various studies and disease models. This review will summarize current research on exosome therapeutics and the application of biomimetic nanoparticles in cardiac regenerative medicine, as well as applications for exosome expansion and delivery on a larger and more clinical scale.

Keywords:

Exosomes, regenerative medicine, biomimetic nanoparticles, drug delivery, extracellular vesicles, mesenchymal stem cells, secretome.

Affiliation:

North Carolina State University, Molecular Biomedical Sciences and Comparative Medicine Institute, 1001 William Moore Dr, North Carolina State University, Molecular Biomedical Sciences and Comparative Medicine Institute, 1001 William Moore Dr, North Carolina State University, Molecular Biomedical Sciences and Comparative Medicine Institute, 001 William Moore Dr., North Carolina State University, Molecular Biomedical Sciences and Comparative Medicine Institute, 1001 William Moore Dr.



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