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Stem cell aging in lifespan and disease: A state-of-the-art review

Author(s):

Saba Sameri, Pouria Samadi, Razieh Dehghan, Elham Salem, Nashmin Fayazi and Razieh Amini*  

Abstract:


Aging considered as inevitable changes at different levels of genome, cell, and organism. From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular communication and exhaustion of stem cells, aging is a major risk factor for many prevalent diseases, such as cancer, cardiovascular disease, pulmonary disease, diabetes, and neurological disorders. The cells are dynamic systems which through a cycle of processes such as replication, growth, and death could replenish the bodies’ organs and tissues, keeping an entire organism in optimal working order. In many different tissues, adult stem cells are behind of these processes, replenishing dying cells to maintain normal tissue function and regenerating injured tissues. Therefore, adult stem cells play a vital role in preventing the aging of organs and tissues, and can delay aging. However, during aging these cells also undergo some detrimental changes such as alterations in the microenvironment, decline in the regenerative capacity, and loss of function. This review aims to discuss age-related changes of stem cells in different tissues and cells including skin, muscles, brain, heart, hair follicles, liver, and lung.

Keywords:

aging, stem cell, age-related diseases, senescence, neurodegeneration, tumor microenvironment

Affiliation:

Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan



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