Tianle Li* and Tao Zhang*
Induction of angiogenesis has enormous potential in the treatment of ischemic diseases and promotion of bulk tissue regeneration. However, poor activity of angiogenic cells and pro-angiogenic factors after transplatation is the main problem that imposes its wide applications. Recent studies have found that the development of nanomaterials has solved this problem to some extent. Nanomaterials can be mainly classified into inorganic nanomaterials represented by metals, metal oxides and metal hydroxides, and organic nanomaterials including DNA tetrahedrons, graphene, graphene oxide and carbon nanotubes. These nanomaterials can induce the release of angiogenic factors either directly or indirectly, thereby initiating a series of signaling pathways to induce angiogenesis. Moreover, appropriate surface modifications of nanomaterial facilitate a variety of functions, such as enhancing its biocompatibility and biostability. In clinical applications, nanomaterials can promote the proliferation and differentiation of endothelial cells or mesenchymal stem cells, thereby promoting the migration of hemangioblast cells to form new blood vessel. This review outlines the role of nanomaterials in angiogenesis and is intended to provide new insights into the clinical treatment of systemic and ischemic diseases.
nanomaterials, angiogenesis, angiogenic factors, endothelial cells, mesenchymal stem cells
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041