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Stem-cell derived exosomes for treatment of osteoarthritis

Author(s):

Zekai Ke and Jinyu Zhu*  

Abstract:


Osteoarthritis (OA) is a common degenerative orthopedic disease with multiple pathologic changes in joints that occurs in large population worldwide. No treatment can reverse the progress of OA. Since exosomes were first reported in 1983, researches have been conducted to explore the mechanisms and therapeutic potential of exosomes in treating OA. Exosomes derived from Mesenchymal stem cells have attracted increasingly attention in tackling disease. This article summarizes the current advances and challenges in exosomes for OA, which may provide reference for further research.

Keywords:

MSC exosomes, Exosomes, Osteoarthritis, Micro-RNA, Cytokines, Microenvironment

Affiliation:

Department of Orthopaedics, Shenzhen University General Hospital´╝îShenzhen University Clinical Medical Academy, Shenzhen, Guangdong Province 518055, Department of Orthopaedics, Shenzhen University General Hospital´╝îShenzhen University Clinical Medical Academy, Shenzhen, Guangdong Province 518055



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