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Roles of Hematopoietic Stem and Progenitor Cells in Ischemic Cardiovascular Disease

Author(s):

Cen Yan, Yu-Ze Li, Xiao-Min Luo, Xiao-Jiang Quan and Ying-Mei Feng*   Pages 1 - 10 ( 10 )

Abstract:


Macrophage proliferation and skewed myelopoiesis-induced monocytosis, as well as neutrophils, enhance the generation of atherogenic inflammatory cells in a lesion area, leading to plaque formation and cardiovascular disease (CVD). Among all risk factors, accumulated data have shown that hyperlipidemia activates hematopoietic stem/progenitor cells (HSPCs) in the bone marrow (BM) niche. Recently, proliferation of granulocyte-monocyte progenitors (GMPs) has been demonstrated to drive skewed myelopoiesis, while HSPCs remain quiescent. In this review, we discuss how HSPCs and GMPs participate in atherosclerosis of mice in terms of proliferation and cell mobilization from BM to peripheral blood and the lesion area. We also describe how the spleen, an extramedullary organ, is involved in skewed myelopoiesis and inflammation in atherosclerosis. We further summarize the clinical evidence of the relationship of HSPCs with coronary stenoses in patients with CVD. Ultimately, this review facilitates understanding the pathological roles of HSPCs and GMPs in atherosclerosis for future treatments.

Keywords:

Myelopoiesis, hematopoietic stem cells, atherosclerosis, hyperlipidemia, niche.

Affiliation:

Beijing Key laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 101149, Department of Nutrition, Province Hospital, He Long Jiang, Ha-Er-Bin 150086, Beijing Key laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 101149, Beijing Key laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 101149, Beijing Key laboratory of Diabetes Prevention and Research, Department of Endocrinology, Lu He hospital, Capital Medical University, Beijing 101149



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