Chang Liu, Yuan He, Xiaobing Xu and Baorong He* Pages 579 - 587 ( 9 )
Excessive bone resorption has been recognized play a major role in the development of bone-related diseases such as osteoporosis, rheumatoid arthritis, Paget's disease of bone, and cancer. Phospholipase Cγ (PLCγ) family members PLCγ1 and PLCγ2 are critical regulators of signaling pathways downstream of growth factor receptors, integrins, and immune complexes and play a crucial role in osteoclast. Ca2+ signaling has been recognized as an essential pathway to the differentiation of osteoclasts. With growing attention and research about natural occurring compounds, the therapeutic use of natural active plant-derived products has been widely recognized in recent years. In this review, we summarized the recent research on PLCγ signaling in bone marrow stem cells and the use of several natural compounds that were proven to inhibit RANKL-mediated osteoclastogenesis via modulating PLCγ signaling pathways.
Phospholipase Cγ signaling, calcium signaling, osteoclast, natural occurring compounds, bone marrow stem cell, osteoporosis.
Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Department of Orthopedics, Fifth Hospital of Xi’an, Xi’an, Department of Neurosurgery, Shunde Hospital of Southern Medical University, Fo Shan, Department of Spine Surgery, Honghui Hospital Affiliated to Xi'an Jiaotong University, Xi'an