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Human Pluripotent Stem Cells for Spinal Cord Injury

Author(s):

Mehdi Forouzesh, Mojgan Hosseini*, Maryam Farzaneh, Mahdieh Azarshab, Amir Anbiyaiee and Seyed Esmaeil Khoshnam   Pages 1 - 9 ( 9 )

Abstract:


Spinal cord injury (SCI) as a serious public health issue and neurological insult is one of the most causes of long-term disability. To date, a variety of techniques have been widely developed to treat central nervous system injury. Currently, clinical treatments are limited to surgical decompression and pharmacotherapy. Because of their negative effects and inefficiency, novel therapeutic approaches in the management of SCI are required. Improvement and innovation of stem cell-based therapies have allowed a huge potential for biological and future clinical applications. Human pluripotent stem cells (hPSCs) including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) are defined by their abilities to divide asymmetrically, self-renew and ultimately differentiate into various cell lineages. There are considerable research efforts to use various types of stem cells such as ESCs, neural stem cells (NSCs), and mesenchymal stem cells (MSCs) in the treatment of patients with SCI. Moreover, the use of patient-specific iPSCs hold great potential as an unlimited cell source for generating in vivo models of SCI. In this review we focused on the potential of hPSCs in treating SCI

Keywords:

Spinal cord injury, Stem cell therapy, Human pluripotent stem cells, Embryonic stem cells, Induced pluripotent stem cells

Affiliation:

Legal medicine Research Center, Legal Medicine Organization, Tehran, Department of Science, Islamshahr Branch, Islamic Azad University, Islamshahr, Tehran, Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Department of Biology, North Tehran Branch, Islamic Azad University, Tehran, Department of Obstetrics & Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61357-15794, Physiology Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz



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