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The Effect of Physical Cues on the Stem Cell Differentiation

[ Vol. 14 , Issue. 3 ]

Author(s):

Mehrdad M. Moghaddam, Shahin Bonakdar, Mona R. Shariatpanahi, Mohammad A. Shokrgozar* and Shahab Faghihi*   Pages 268 - 277 ( 10 )

Abstract:


Development of multicellular organisms is a very complex and organized process during which cells respond to various factors and features in extracellular environments. It has been demonstrated that during embryonic evolvement, under certain physiological or experimental conditions, unspecialized cells or stem cells can be induced to become tissue or organ-specific cells with special functions. Considering the importance of physical cues in stem cell fate, the present study reviews the role of physical factors in stem cells differentiation and discusses the molecular mechanisms associated with these factors.

Keywords:

Stem cell, differentiation, physical cues, molecular mechanisms, growth, differentiation, apoptosis.

Affiliation:

Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, 14965/161, National Cell Bank, Pasteur Institute of Iran, Tehran 3159915111, Department of Biochemistry, Payame Noor University, Tehran, National Cell Bank, Pasteur Institute of Iran, Tehran 3159915111, Stem Cell and Regenerative Medicine Group, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, 14965/161



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