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Stem Cells and Endometrial Regeneration: From Basic Research to Clinical Trial

[ Vol. 14 , Issue. 4 ]

Author(s):

Xinxin Zhu, Bruno Péault, Guijun Yan, Haixiang Sun, Yali Hu and Lijun Ding*   Pages 293 - 304 ( 12 )

Abstract:


Monthly changes in the endometrial cycle indicate the presence of endometrial stem cells. In recent years, various stem cells that exist in the endometrium have been identified and characterized. Additionally, many studies have shown that bone marrow mesenchymal stem cells (BM-MSCs) provide an alternative source for regenerating the endometrium and repairing endometrial injury. This review discusses the origin of endometrial stem cells, the characteristics and main biomarkers among five types of putative endometrial stem cells, applications of endometrium-derived stem cells and menstrual blood-derived stem cells, the association between BM-MSCs and endometrial stem cells, and progress in repairing endometrial injury.

Keywords:

Endometrial stem cells, label-retaining cells, side population cells, menstrual blood-derived stem cells, bone marrow- derived stem cells, Asherman’s syndrome.

Affiliation:

Center for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu, MRC Center for Regenerative Medicine, University of Edinburgh, Edinburgh, EH16 4UU, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, Center for Reproductive Medicine, Drum Tower Clinic Medical College of Nanjing Medical University, Nanjing 210029, Jiangsu



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