Wei Zhou, Ming Qu, Yajie Lv and Jinyu Zhu* Pages 226 - 229 ( 4 )
Osteonecrosis of the femoral head (ONFH) is a common refractory orthopedic disease with multiple etiologies that more frequently occurs in middle-aged and young people. ONFH is the main cause of hip replacement in young patients. Since Professor Hernigou first reported the use of stem cells in the treatment of early stage ONFH, a large number of studies have demonstrated the potential of stem cells in the treatment of adult patients with ONFH. With the rise of interdisciplinary stem cell therapy combined with platelet-rich plasma therapy, gene therapy or other methods have gradually attracted the attention of researchers. This article summarizes the current advances in stem cell therapy for ONFH, as well as the problems and challenges, which may provide reference for further research.
Stem cells, cell therapy, osteonecrosis of the femoral head, mesenchymal stem cells, gene therapy, trauma.
Department of Orthopaedics, Chengdu Military General Hospital, Chengdu, Sichuan Province 610036, Department of Orthopaedics, Fuping Couty Hospital, Fuping, Shaanxi Province, 711700, Institute of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 71000, Institute of Orthopaedic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 71000