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A Mini-Review: The Therapeutic Potential of Bone Marrow Mesenchymal Stem Cells and Relevant Signaling Cascades

[ Vol. 14 , Issue. 3 ]


Wen Yang and Bo Ma*   Pages 214 - 218 ( 5 )


Bone marrow mesenchymal stem cells (BMSCs) characterized multi-directional differentiation, low immunogenicity and high portability, serve as ideal “seed cells” in ophthalmological disease therapy. Therefore, in this mini-review, we examined the recent literature concerning the potential application of BMSCs for the treatment of ophthalmological disease, that includes: the cellular activity of BMSCs transplantation, migration and homing, as well as the immuno-modulatory and antiinflammatory effects of BMSCs and signaling involved. Each aspect is complementary to the others and together these aspects promoted further understanding of the potential use of BMSCs in treating ophthalmological diseases.


BMSCs, signaling, ophthalmological, bone marrow, mesenchymal stem cells, embryogenesis.


Department of Ophthalmology, Xi'an Fourth Hospital, Xi'an Shaanxi, 710000, Department of Ophthalmology, Xi'an Fourth Hospital, Xi'an Shaanxi, 710000

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