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Breast Cancer Stem Cells and Sex Steroid Hormones

[ Vol. 14 , Issue. 5 ]

Author(s):

Ivan Flores-Ramirez, Noemi Baranda-Avila* and Elizabeth Langley   Pages 398 - 404 ( 7 )

Abstract:


Breast cancer stem cells (BCSCs) are a small population of tumor-initiating cells that express stem cell-associated markers. In recent years, their properties and mechanisms of regulation have become the focus of intense research due to their intrinsic resistance to conventional cancer therapies. This review describes breast cancer stem cell origin, signaling pathways involved in self-renewal, such as Wnt, Notch and Hedgehog, biomarkers linked to stemness, and the role of sex steroid hormones in BCSC regulation.

Keywords:

Breast cancer, breast cancer stem cells, biomarkers, signaling pathways, estrogen receptor, progesterone receptor.

Affiliation:

Programa de Doctorado en Ciencias Biomedicas, Universidad Nacional Autonoma de Mexico. CDMX., Departamento de Investigacion Basica, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Col. Seccion XVI, Tlalpan 14080, CDMX., Departamento de Investigacion Basica, Instituto Nacional de Cancerologia, Av. San Fernando No. 22, Col. Seccion XVI, Tlalpan 14080, CDMX.



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