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Exploring Confluence-Related Signalling to Modulate the Expression of Oct4 – A Role in Facilitating Mouse Somatic Cell Reprogramming?

[ Vol. 13 , Issue. 8 ]

Author(s):

Yu-Qiang Li*   Pages 676 - 681 ( 6 )

Abstract:


Oct4 is uniformly expressed by all types of pluripotent cells and is essential for pluripotency. Oct4 is also the central reprogramming factor that is constant in most transcription factor cocktails used to generate iPS cells. This article discusses the mechanisms of regulating Oct4 expression by confluence-based Hgf and hypoxia signalling in mouse somatic cells. Stat3 is activated ligandindependently in confluent cells and triggers the formation of cell aggregates. Hgf signalling is preserved after confluence, stimulating

Keywords:

Octamer-binding transcription factor 4, expression regulation, confluence, hepatocyte growth factor, hypoxia, mice.

Affiliation:

Marine college, Shandong University (Weihai), Weihai



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