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Updates on GMSCs Treatment for Autoimmune Diseases

[ Vol. 13 , Issue. 5 ]

Author(s):

Feng Huang, Zhong Ming Liu and Song Guo Zheng*   Pages 345 - 349 ( 5 )

Abstract:


Background: Autoimmune disease is a refractory disease. Accumulating Evidence has revealed that the manipulation of mesenchymal stem cells may have the potential to control or even treat autoimmune diseases. Human gingiva-derived mesenchymal stem cells (GMSCs) are emerging as a new line of mesenchymal stem cells that have displayed some potential advantages in controlling and treating autoimmune diseases.

Objective: In this review, we briefly update the current understanding on the biology of GMSCs and their effects on preventing and treating autoimmune diseases.

Conclusion: The availability of gingival mesenchymal stem cells (GMSCs), together with their potent capacity of multi-directional differentiation and inflammatory modulation, making GMSCs an ideal subtype of MSCs in treating autoimmune disease. Our and other studies have launched the earliest appraisal on GMSCs and carried out a lot of biological researches. The clinical trial of GMSCs on patients with autoimmune diseases will further approve their therapeutic effects, as well as its cellular and molecular mechanisms.

Keywords:

Autoimmune diseases, mesenchymal stem cells, human gingiva-derived mesenchymal stem cells, bone marrowderived mesenchymal stem cells, cell therapy.

Affiliation:

Department of Clinical Immunology, Third Hospital at Sun Yat-sen Universirty, Guangzhou, 510630, Institute of Immunology, Shanghai East Hospital at Tongji University, Shanghai, 200120, Department of Medicine, Milton S. Hershey Medical Center, Penn State University, Hershey, PA, 17033



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