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Immunomodulatory Effect of Cytokines in the Differentiation of Mesenchymal Stem Cells: A Review

[ Vol. 12 , Issue. 3 ]

Author(s):

Wafa Zahari, Siti Nurnasihah Md Hashim, Muhammad Fuad Hilmi Yusof, Zul Faizuddin Osman, Thirumulu Ponnuraj Kannan, Khairani Idah Mokhtar, Azlina Ahmad and Khairul Bariah Ahmad Amin Noordin   Pages 197 - 206 ( 10 )

Abstract:


Mesenchymal stem cells (MSCs) are stromal origin cells with multilineage differentiation capacity. The immunoregulatory properties of MSCs can be interfered effectively by cytokines. Cytokines, produced by a broad range of cells, act at the systemic level to influence biological phenomena such as inflammation, wound healing, organogenesis and oncogenesis. Cytokines also play vital roles in the differentiation of MSCs into several cell lineages. This review summarizes on how cytokines can affect MSCs differentiation and their relative signaling pathways, which may serve to understand the possible underlying mechanisms. Also, this review reveals the potential clinical use of MSCs as promising therapeutic agents due to their special characteristics such as multipotent differentiation, immunomodulatory properties, and selfrestoration.

Keywords:

Adipogenesis, chondrogenesis, immunomodulatory cytokines, mesenchymal stem cells, odontogenesis, osteogenesis.

Affiliation:

School of Dental Sciences, Universiti Sains Malaysia, Kelantan,, School of Dental Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan



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