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Double-Faced Role of Human Mesenchymal Stem Cells and their Role/Challenges in Cancer Therapy

[ Vol. 11 , Issue. 4 ]

Author(s):

Nedime Serakinci, Rasime Kalkan and Pinar Tulay   Pages 343 - 351 ( 9 )

Abstract:


Human mesenchymal stem cells (hMSCs) are multipotent non-hematopoietic precursor cells with the ability to differentiate into several tissue types. The use of hMSCs has gained significant importance in cancer therapies as well as a large number of degenerative disease therapies due to their homing abilities. However, these cells may undergo spontaneous transformation leading to them bypassing naturally built-in cell controls that could lead to senescence and carcinogenesis. Therefore, although MSCs have great potential for cancer therapy, they also risk the development of cancer, which provides them with double-faced characteristics for both cancer development and therapy. The potential use of hMSCs in therapeutics from the aspect of in vitro expansion of hMSCs and telomere dynamic is discussed.

Keywords:

Cancer therapy, differentiation, mesenchymal stem cells, neoplastic transformation, telomere.

Affiliation:

Faculty of Medicine, Department of Medical Genetics, Near East University, Yakin Dogu Bulvari, Nicosia, Cyprus, Turkey.



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