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Umbilical Cord is a Rich Source of Mesenchymal Stromal Cells for Cell Therapy

[ Vol. 11 , Issue. 8 ]

Author(s):

Tokiko Nagamura-Inoue and Takeo Mukai   Pages 634 - 642 ( 9 )

Abstract:


Recently, umbilical cord (UC) and UC-derived mesenchymal stromal cells (UC-MSCs) have attracted much attention for many reasons, including (1) abundant sources and ease of collection, storage, and transport; (2) little ethical controversy; (3) multipotency to differentiate into various cell types; and (4) low immunogenicity with significant immunosuppressive ability. In this review, we provide a brief introduction to UC and UC-MSCs in terms of characteristics, isolation, and cryopreservation, as well as emphasizing their potential clinical application in regenerative medicine and immunotherapy.

Keywords:

Cryopreservation, explant, immunosuppression, mesenchymal stromal cells, stem cell therapy, umbilical cord.

Affiliation:

Department of Cell Processing and Transfusion, Research Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo, Japan.



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