Soumya Pati, Sangu Muthuraju, Raisah Ab. Hadi, Tee Jong Huat, Shailja Singh, Mirjana Maletic-Savatic, Jafri Malin Abdullah and Hasnan Jaafar Pages 149 - 157 ( 9 )
Traumatic brain injury (TBI) imposes horrendous neurophysiological alterations leading to most devastating forms of neuro-disability. Which includes impaired cognition, distorted locomotors activity and psychosomatic disability in both youths and adults. Emerging evidence from recent studies has identified mesenchymal stem cells (MSCs) as one of the promising category of stem cells having excellent neuroregenerative capability in TBI victims. Some of the clinical and animal studies reported that MSCs transplantation could cure neuronal damage as well as improve cognitive and locomotors behaviors in TBI. However, mechanism behind their broad spectrum neuroregenerative potential in TBI has not been reviewed yet. Therefore, in the present article, we present a comprehensive data on the important attributes of MSCs, such as neurotransdifferentiation, neuroprotection, axonal repair and plasticity, maintenance of blood-brain integrity, reduction of reactive oxygen species (ROS) and immunomodulation. We have reviewed in detail the crucial neurogenic capabilities of MSCs in vivo and provided consolidated knowledge regarding their cellular remodeling in TBI for future therapeutic implications.
Immunomodulation and therapeutic, mesenchymal stem cells, neuro-transdifferentiation, traumatic brain injury.
Center for Neurosciences Services and Research, Universiti Sains Malaysia Hospital, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia., Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Jalan Hospital Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia.