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The Influence of Diabetes Mellitus on Proliferation and Osteoblastic Differentiation of MSCs

[ Vol. 12 , Issue. 5 ]

Author(s):

Jun Tan, Lihua Zhou, Yang Zhou, Peng Xue, Guangsheng Wu, Guangying Dong, Hang Guo and Qintao Wang   Pages 388 - 400 ( 13 )

Abstract:


Background: Diabetes mellitus (DM) is a widespread chronic metabolic disease which has high mortality due to its complications. In addition to traditional medication, stem cell transplantation therapeutics has become a brand-new and prospective remedy for DM. With strong self-renewal and multi-potential ability, mesenchymal stem cells (MSCs) are considered as ideal cell sources of cell therapy for DM and many other diseases. However, not only do endogenous MSCs fail to replace the impaired islet cells, but also transplanted MSCs fail to cure many patients complicated with DM. Besides, quite a few DM patients suffer from high risk of fracture and low efficiency of bone regeneration, which are often associated with the osteoblastic differentiation of MSCs. Recently, a number of researches have investigated that the changes in micro-environment by DM can affect biological characteristics of MSCs through many factors.

Summary: In this review, we summarize the developments in the influence of DM on proliferation and osteoblastic differentiation of MSCs, and moreover, osteoporosis, obesity and metabolism syndrome, as they are closely related to DM.

Keywords:

Diabetes mellitus, mesenchymal stem cells, proliferation, osteoblastic differentiation, osteoporosis, obesity, metabolism syndrome,

Affiliation:

State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi`an, Shaanxi, Department of Stomatology, General Hospital of Beijing Military Area, Beijing, Department of Anesthesiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou, Guangdong, State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi`an, Shaanxi, State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi`an, Shaanxi, State Key Laboratory of Military Stomatology, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, Xi`an, Shaanxi, Department of Anesthesiology, General Hospital of Beijing Military Area, Beijing, Department of Periodontology, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, Xi`an, Shaanxi 710032, P. R. China



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