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The Role of Bioreactors in Ligament and Tendon Tissue Engineering

[ Vol. 11 , Issue. 1 ]

Author(s):

James Mace, Andy Wheelton, Wasim S. Khan and Sanj Anand   Pages 35 - 40 ( 6 )

Abstract:


Bioreactors are pivotal to the emerging field of tissue engineering. The formation of neotissue from pluripotent cell lineages potentially offers a source of tissue for clinical use without the significant donor site morbidity associated with many contemporary surgical reconstructive procedures. Modern bioreactor design is becoming increasingly complex to provide a both an expandable source of readily available pluripotent cells and to facilitate their controlled differentiation into a clinically applicable ligament or tendon like neotissue. This review presents the need for such a method, challenges in the processes to engineer neotissue and the current designs and results of modern bioreactors in the pursuit of engineered tendon and ligament.

Keywords:

Bioreactors, flow perfusion, ligament, rotating wall, spinner flasks, tendon.

Affiliation:

University College London Institute of Orthopaedics and Musculoskeletal Science, Royal National Orthopaedic Hospital, Stanmore, London, HA7 4LP, UK.



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