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Mesenchymal Stem Cells in the Treatment of Amyotrophic Lateral Sclerosis

[ Vol. 11 , Issue. 1 ]


Mahsa Hajivalili, Fatemeh Pourgholi, Hossein Samadi Kafil, Farhad Jadidi-Niaragh and Mehdi Yousefi   Pages 41 - 50 ( 10 )


Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder which is characterized by motor neuron (MN) dysfunction, progressive paralysis, and death. Although several therapeutic approaches have been used for treatment of ALS, little success has been achieved. Natural vectors such as mesenchymal stem cells (MSCs) can be a promising tool for overcoming therapeutic problems. MSCs have multipotential characteristics such as the ability to differentiate into variety of cell types, easy access, immunomodulation, tissue repair, exertion of trophic factors, exosome secretion and efficient homing. In this review, we will discuss the characteristics of MSCs and their possible therapeutic mechanisms in ALS patients.


Amyotrophic lateral sclerosis, mesenchymal stem cells, stem cell, treatment.


Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

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