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Peroxisome Proliferator-Activated Receptor (PPAR) in Regenerative Medicine: Molecular Mechanism for PPAR in Stem Cells’ Adipocyte Differentiation

[ Vol. 11 , Issue. 3 ]

Author(s):

Qiang Xie, Taoran Tian, Zhaozhao Chen, Shuwen Deng, Ke Sun, Jing Xie and Xiaoxiao Cai   Pages 290 - 298 ( 9 )

Abstract:


Regenerative medicine plays an indispensable role in modern medicine and many trials and researches have therefore been developed to fit our medical needs. Tissue engineering has proven that adipose tissue can widely be used and brings advantages to regenerative medicine. Moreover, a trait of adipose stem cells being isolated and grown in vitro is a cornerstone to various applications. Since the adipose tissue has been widely used in regenerative medicine, numerous studies have been conducted to seek methods for gaining more adipocytes. To investigate molecular mechanism for adipocyte differentiation, peroxisome proliferator-activated receptor (PPAR) has been widely studied to find out its functional mechanism, as a key factor for adipocyte differentiation. However, the precise molecular mechanism is still unknown. This review thus summarizes recent progress on the study of molecular mechanism and role of PPAR in adipocyte differentiation.

Keywords:

Adipogenesis, adipose derived stem cell, marrow stem cell, peroxisome proliferator-activated receptor, regenerative medicine, soft tissue defect.

Affiliation:

State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, No.14, 3rd Sec, Ren Min Nan Road, Chengdu, 610041. P.R. China.



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