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Stem Cell and Idiopathic Pulmonary Fibrosis: Mechanisms and Treatment

[ Vol. 10 , Issue. 6 ]

Author(s):

Ming Liu, Dunqiang Ren, Dong Wu, Jian Zheng and Wenwei Tu   Pages 466 - 476 ( 11 )

Abstract:


Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease resulting from multiplex causes. Evidence indicates that stem/progenitor cells might play a key role in IPF pathogenesis and repair, which may provide some novel potential strategies for the future treatment of IPF. In this review, we first summarize the current understanding of the relationship between stem cells and IPF and then review the advancements made in recent clinical trials using stem/progenitor cells, especially mesenchymal stem cells, in treating IPF and their interpretations.

Keywords:

Embryonic stem cells, induced pluripotent stem cells, mesenchymal stem cells, pulmonary fibrosis, treatment.

Affiliation:

Department of Pediatrics and Adolescent Medicine Li Ka Shing Faculty of Medicine, The University of Hong Kong China.



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