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Preclinical and Clinical Studies on the Use of Stem Cells for Bone Repair: A Systematic Review

[ Vol. 8 , Issue. 3 ]

Author(s):

Anuruthran Ambikaipalan, James Min-Leong Wong and Wasim S. Khan   Pages 210 - 216 ( 7 )

Abstract:


The management of extensive bone defects in the setting of fracture repair, non-union and revision arthroplasty are challenging problems. The supply of harvestable autologous bone graft is limited, with an associated morbidity, and therefore a need exists for a better solution in large defects. The use of stem cells is an evolving field of research, with different potential applications, ranging from simple injection of cells to tissue engineering using osteogenic cells seeded onto a scaffold.

This systematic review aims to collate the published preclinical and clinical studies investigating the potential use of stem cells for bone repair.

Keywords:

Bone repair, scaffolds, stem cells, tissue engineering

Affiliation:

Department of Trauma and Orthopaedics, Royal Melbourne Hospital, Parkville, Victoria 3052, Australia.



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